Last edited by Mojas
Saturday, August 1, 2020 | History

6 edition of Methods for structural analysis of protein pharmaceuticals / Wim Jiskoot, Daan J.A. Crommelin. found in the catalog.

Methods for structural analysis of protein pharmaceuticals / Wim Jiskoot, Daan J.A. Crommelin.

by Wim Jiskoot

  • 194 Want to read
  • 4 Currently reading

Published by AAPS Press in New York .
Written in English

    Subjects:
  • Protein drugs -- Analysis

  • Edition Notes

    Includes index.

    SeriesBiotechnology: pharmaceutical aspects ;, 3, Biotechnology (Arlington, Va.) ;, 3.
    ContributionsCrommelin, D. J. A.
    Classifications
    LC ClassificationsRS431.P75 J55 2005
    The Physical Object
    Paginationp. cm.
    ID Numbers
    Open LibraryOL3420931M
    ISBN 100971176728
    LC Control Number2005041029

    Protein oxidation may result in loss of biological activity and other undesirable pharmaceutical consequences. Strategies to stabilize proteins against oxidation can be classified into intrinsic methods (site‐directed mutagenesis and chemical modification), physical methods (solid vs. liquid formulations) and use of chemical additives. Daan J. A. Crommelin, Robert D. Sindelar, Bernd Meibohm This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with .

    Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable interest from . Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and Price: $

    Type: BOOK - Published: - Publisher: John Wiley & Sons Get Books This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory.   1. Introduction. Recent developments in biotechnology have resulted in a rapidly increasing number of therapeutic proteins. The relative instability of new potential protein therapeutics requires systematic approaches to rationally design stable protein formulations (Carpenter and Manning, , Crommelin and Sindelar, ).In the presence of water proteins can undergo a variety of .


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Methods for structural analysis of protein pharmaceuticals / Wim Jiskoot, Daan J.A. Crommelin by Wim Jiskoot Download PDF EPUB FB2

Protein pharmaceuticals form a fast-growing category in the arsenal of drugs. In the coming years, the patents on a number of the first-generation protein pharmaceuticals will expire, opening the door for the development of biogenerics into the market.

However, it is very difficult to characterize. Methods for Structural Analysis of Protein Pharmaceuticals (Biotechnology: Pharmaceutical Aspects (III)): Medicine & Health Science Books @ Wim Jiskoot (Editor), Daan Crommelin (Editor) ISBN ISBN Why is Price: $   Protein pharmaceuticals form a fast-growing category in the arsenal of drugs.

This book explores the nature of different analytical techniques and the way in which they are related to pharmaceutical proteins. In addition to serving the analytical chemist, this book is needed by the formulation scientist who is responsible for design and formulation of a pharmaceutical protein that.

Herron, James N. (ed.), Jiskoot, Wim (ed.), Crommelin, Daan J. (ed.) Illustrationer XVIII, p. Volymtitel Physical Methods to Characterize Pharmaceutical Proteins Dimensioner x x 22 mm Vikt g Antal komponenter 1 Komponenter 1 Hardback ISBN Request PDF | On Jan 1,L.A.

Kueltzo and others published Methods for Structural Analysis of Protein Pharmaceuticals | Find, read and cite all the research you need on ResearchGate. Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools.

Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and. ISBN: OCLC Number: Description: xvii, pages: illustrations ; 24 cm: Contents: Ch. Application of Fluorescence Spectroscopy for Determining the Structure and Function of Proteins / Wim Jiskoot, Vladimir Hlady, John J.

Naleway and James N. Herron --Ch. ural Information on Proteins from Circular Dichroism Spectroscopy: Possibilities and. Get this from a library.

Physical methods to characterize pharmaceutical proteins. [James N Herron; Wim Jiskoot; D J A Crommelin;] -- This collection of state-of-the-art research describes the most frequently used techniques for structural analysis of proteins. Chapters focus on the impressive progress that has been made in the.

This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements.

Analytical methods covered in the book include separation, light scattering, microscopy, and. Wim Jiskoot, Vladimir Hlady, John J.

Naleway, James N. Herron Pages Structural Information on Proteins from Circular Dichroism Spectroscopy Possibilities and Limitations. Methods for Structural Analysis of Protein Pharmaceuticals. Edited by Wim Jiskoot and Daan Crommelin, Utrecht University. Open image in new window.

This book is Volume 3 of the Biotechnology: Pharmaceutical Aspects series from AAPS Press. Wim Jiskoot Bernard Metz Enzymatic degradation of protein antigens by endo-lysosomal proteases in antigen-presenting cells is crucial for achieving cellular immunity.

The need for manufacturers of pharmaceutical protein products to evaluate and control this risk to product quality is underscored by published case studies with therapeutic proteins in which subvisible particles were measured.

8,15,16 For example, during filling pump operations, it was found that an IgG formed hundreds of thousand of particles. Protein structures can be analyzed by some methods such as circular dichroism (CD), nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography, and electron microscopy which are discussed later (Kamp et al., ; Jiskoot and Crommelin, ).

Pharmaceutical Biotechnology: Physical Methods to Characterize Pharmaceutical Proteins (Paperback) Average Rating: () stars out of 5 stars Write a review James N Herron; Wim Jiskoot; Daan J a Crommelin.

Author(s): Jiskoot,Wim; Crommelin,D J A(Daan J. A.); American Association of Pharmaceutical Scientists. Title(s): Methods for structural analysis of protein. AAPS Update AAPS Update AAPS Update AAPSY YOUR FORMULA FOR SUCCESS.

December st Pharmacokinetics in Drug Development: AAPS 41 Annual Pharmaceutical Regulatory and Development Paradigms (Volume 2) Technologies Conference— Edited by Peter Bonate and Danny Howard Formerly at Arden House: Oral.

John F. Carpenter, Theodore W. Randolph, Wim Jiskoot, Daan J.A. Crommelin, C. Russell Middaugh and Gerhard Winter, Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: Essential need to use orthogonal methods to assure the quality of therapeutic protein products, Journal of Pharmaceutical Sciences.

Bremer Particle Van den A. Heck () Mass spectrometry: protein conformational analysis and molecular recognition W. Jiskoot D. Crommelin (Eds) Methods for Structural Analysis of Protein Pharmaceuticals SeriesTitle Vol. 3, Biotechnology: Pharmaceutical Aspects AAPS Press Arlington –   Methods for Structural Analysis of List Price: $, AAPS Member $ Protein Pharmaceuticals Edited by Wim Jiskoot and Daan Crommelin, Pharmacokinetics in Drug Development: Regulatory Utrecht University.

and Development Paradigms (Volume 2) This book is volume 3 of the Biotechnology: Pharmaceutical Aspects series from AAPS Press. Methods for Structural Analysis of Protein Pharmaceuticals (Biotechnology: Pharmaceutical Aspects) 1st edition by Jiskoot, Wim published by American Assoc.

of Pharm. Scientists Hardcover on *FREE* shipping on qualifying offers. Methods for Structural Analysis of Protein Pharmaceuticals (Biotechnology: Pharmaceutical Aspects) 1st edition by JiskootManufacturer: American Assoc.

of Pharm. Scientists.Pharmaceutical Biotechnology | Daan J. A. Crommelin, Robert D. Sindelar and Bernd Meibohm | download | B–OK. Download books for free.

Find books.Referanslar. 1) Methods for Structural Analysis for Protein Pharmaceutics. Ed.: Jiskoot, W., Crommelin, D., Springer Science & Business Media,